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New approaches to study bone regeneration

A number of new technologies have been developed to study bone regeneration in organ culture and/or in animals. Next-generation sequencing methods, such as scRNAseq (as described above), have made it possible to identify cell subtypes and to understand the complex tissue regeneration process in an unbiased way, which was challenging before the advent of these technologies.

Organ culture

Organ culture, which relies on the maintenance of an immature organ such as a fetal organ or adult organ explant, may be used to investigate molecular mechanisms underlying organ development or regeneration. It may be used in studies to simulate human diseases or to interrogate ‘pharmacology’, such as those using small molecules or monoclonal antibodies that are designed to modulate cell–cell or cell–extracellular matrix interactions. Organ culture systems are

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“A source close to me says the real exciting part of Michael Jackson’s death is that everyone is pitching in.” Which seemed like a safe prediction considering Michael had thousands of products named after him and his music was virtually ubiquitous, and in a panic, they’re all buying his stuff out of guilt-led impulse.

It’s just a little bit sad to see the steady drip of Jackson-related money into his heirs’ bank accounts. The first big winner of course is Lisa Marie Presley, who is spending $600,000 to remodel the “Frank” that Michael had carved for her./*
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package org.apache.druid.data.input;

import com.fasterxml.jackson.annotation.JsonSubTypes;
import com.fasterxml.jackson.annotation.JsonTypeInfo;
import com.fasterxml.jackson.annotation.JsonTypeName;
import org.apache.druid.data.input.impl.MapValueInputFormat;
import org.apache.druid.data.input.impl.ObjectValueInputFormat;
import org.apache.druid.data.input.impl.PrimitiveValueInputFormat;
import org.apache.druid.java.util.common.StringUtils;
import org.apache.d


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